Author: Zhao, Jingxian; Zhao, Jincun; Fett, Craig; Trandem, Kathryn; Fleming, Erica; Perlman, Stanley
Title: IFN-?– and IL-10–expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis Document date: 2011_8_1
ID: k751ryv4_7
Snippet: Foxp3 gfp mice were infected with rJ2.2 and examined for the presence of Foxp3 + T reg cells. The frequency of Foxp3 + T reg cells was 20-30% at 3 and 5 d after infection, decreasing to <10% of total CD4 T cells in the brain and spinal cord by 7 d after infection (Fig. 1 A) . The decrease in frequency by day 7 did not reflect a lower rate of proliferation because similar fractions of T reg cells and non-T reg CD4 T cells incorporated BrdU at 6 d .....
Document: Foxp3 gfp mice were infected with rJ2.2 and examined for the presence of Foxp3 + T reg cells. The frequency of Foxp3 + T reg cells was 20-30% at 3 and 5 d after infection, decreasing to <10% of total CD4 T cells in the brain and spinal cord by 7 d after infection (Fig. 1 A) . The decrease in frequency by day 7 did not reflect a lower rate of proliferation because similar fractions of T reg cells and non-T reg CD4 T cells incorporated BrdU at 6 d after infection (Fig. 1 B) . Rather, it likely reflects recruitment of virus-nonspecific T reg cells into the CNS at early stages of the infection.
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