Selected article for: "Frameshift efficiency and thermodynamic stability"
Author: Mouzakis, Kathryn D.; Lang, Andrew L.; Vander Meulen, Kirk A.; Easterday, Preston D.; Butcher, Samuel E.
Title: HIV-1 frameshift efficiency is primarily determined by the stability of base pairs positioned at the mRNA entrance channel of the ribosome
  • Document date: 2012_12_15
    • ID: ix8du1er_4
    Snippet: An important role of the downstream structure is to induce ribosomal pausing on the slippery sequence, which is necessary but not sufficient to promote efficient levels of frameshifting (40) (41) (42) . Interestingly, the pause length does not appear to correlate with frameshift efficiency (40) . Interactions with the translational machinery have also been hypothesized to contribute to frameshifting (5, 23, 31, 32, 43) . Previous studies have obs.....
    Document: An important role of the downstream structure is to induce ribosomal pausing on the slippery sequence, which is necessary but not sufficient to promote efficient levels of frameshifting (40) (41) (42) . Interestingly, the pause length does not appear to correlate with frameshift efficiency (40) . Interactions with the translational machinery have also been hypothesized to contribute to frameshifting (5, 23, 31, 32, 43) . Previous studies have observed general trends between HIV-1 stem-loop thermodynamic stability and frameshift efficiency (30, 44, 45) . However, a quantitative correlation between thermodynamic stability and frameshift efficiency has not been described, and the role of individual base pairs has not been systematically investigated.

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