Author: Lin, Yung-Sheng; Lee, Ming-Yuan; Yang, Chih-Hui; Huang, Keng-Shiang
Title: Active Targeted Drug Delivery for Microbes Using Nano-Carriers Document date: 2015_8_23
ID: kpcb2vy4_5
Snippet: One of the important prerequisites of a drug delivery system is to send a therapeutic agent effectively to the pathologic site as soon as it can [41] . Active targeted strategy is the prospective approach for drug delivery [32, 40] . Active strategies have introduced by Paul Ehrlich and known for 'magic bullet' to describe this system [42] . This system can reach the intended site in higher concentrations in the short period of time. Active targe.....
Document: One of the important prerequisites of a drug delivery system is to send a therapeutic agent effectively to the pathologic site as soon as it can [41] . Active targeted strategy is the prospective approach for drug delivery [32, 40] . Active strategies have introduced by Paul Ehrlich and known for 'magic bullet' to describe this system [42] . This system can reach the intended site in higher concentrations in the short period of time. Active targeted delivery is believed that it can improve efficacy while reducing unpleased side-effects. Some certain bacteria, fungi and all viruses are intracellular parasites [43] . As they are growing and reproducing inside the special host cells, scientists could create an active targeted drug delivery system that copied cells infected by those parasites [44] . Active targeted strategies used curtained ligands such as antibodies, peptides, nano-bodies, sugar molecules and aptamers on surface of nano-carriers to improve therapeutic efficacy [45, 46] . Most common seen nano-carriers are liposomes [47] [48] [49] [50] [51] , nanoparticles [52] [53] [54] [55] [56] , dendrimers [57] [58] [59] and carbon nanotubes [60] [61] [62] , and the others.. core frequently used as platforms in pharmaceuticals and cosmetics for drug release [63] [64] [65] . This unique dual release capability makes the delivery of two types of substances in the same time [66] . The first FDA-approved liposomal drug, doxorubicin-encapsulated PEGylated liposomes for curing AIDS connected Kaposi's sarcoma, begun production in 1995 [67] . Composed of natural lipids, liposomes are low toxicity, ease of preparation and high biodegradability [68] . In hence, it works well with a wide range of agents to facilitate a targeted delivery by means of abovementioned characteristics from liposomes [69] . Liposomes binding different specific ligands on their surface such as glycerolipids of Archaea (Archaeosomes) or virus glycoprotein/antigens (virosomes) could display immunoadjuvant potential for a vaccine and higher affinity to the targeted sites than the free drug [66] . The details of references connected with binding ligands for treatment of diseases resulted from microbes are summarized in (Table 1 ).
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