Author: Cobo, Fernando
Title: Application of Molecular Diagnostic Techniques for Viral Testing Document date: 2012_11_30
ID: jiy4cp4n_13
Snippet: For the detection of HCV, the first-generation bDNA assay (Quantiplex HCV RNA 1.0 assay, Bayer) had a dynamic quantification range in human plasma (from 3.5 x 10 5 to 1.2 x 10 8 HCV RNA copies/mL). Genotypes 1-6 were detected by using this assay, although the sensitivity was lower for genotypes 2 and 3. To improve the detection rate for HCV genotypes 2 and 3, a second-generation assay was developed (Quantiplex HCV RNA 2.0 assay, Bayer). However, .....
Document: For the detection of HCV, the first-generation bDNA assay (Quantiplex HCV RNA 1.0 assay, Bayer) had a dynamic quantification range in human plasma (from 3.5 x 10 5 to 1.2 x 10 8 HCV RNA copies/mL). Genotypes 1-6 were detected by using this assay, although the sensitivity was lower for genotypes 2 and 3. To improve the detection rate for HCV genotypes 2 and 3, a second-generation assay was developed (Quantiplex HCV RNA 2.0 assay, Bayer). However, a third-generation bDNA assays both for HCV and HIV have been developed (VERSANT HCV RNA 3.0 and VERSANT HIV-1 RNA 3.0 assays, Bayer) that uses isoC and isoG-substituted oligonucleotides to reduce nonspecific hybridization.
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