Author: Casanova, Victor; Sousa, Filipa H; Stevens, Craig; Barlow, Peter G
Title: Antiviral therapeutic approaches for human rhinovirus infections Document date: 2018_6_12
ID: kl7holv4_9
Snippet: At last, in vitro studies and clinical trials have suggested that the red seaweed polysaccharide, carrageenan, has antiviral activity against RV both in vitro and in vivo. Iota-carrageenan, a sulphated variety, was demonstrated to prevent the replication of RV-1A, 2, 8, 14, 16, 83 and 84 in nasal epithelium [66] . A clinical trial examining the effect of iota-carrageenan containing nasal spray found that patients found to be positive for RV infec.....
Document: At last, in vitro studies and clinical trials have suggested that the red seaweed polysaccharide, carrageenan, has antiviral activity against RV both in vitro and in vivo. Iota-carrageenan, a sulphated variety, was demonstrated to prevent the replication of RV-1A, 2, 8, 14, 16, 83 and 84 in nasal epithelium [66] . A clinical trial examining the effect of iota-carrageenan containing nasal spray found that patients found to be positive for RV infection and treated with nasal spray demonstrated a significant reduction in the duration of symptoms and enhanced resolution of the infection when compared with placebo control [67] .
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