Selected article for: "adenovirus infection and dna replication"
Author: Lam, Yun W.; Evans, Vanessa C.; Heesom, Kate J.; Lamond, Angus I.; Matthews, David A.
Title: Proteomics Analysis of the Nucleolus in Adenovirus-infected Cells
  • Document date: 2009_10_7
    • ID: jgxbpy4j_1
    Snippet: nucleus are inhibited, and a number of viral nucleolar antigens accumulate in the nucleoli of infected cells (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) . Moreover, two cellular nucleolar antigens, UBF 1 and B23.1, have been shown to be sequestered into viral DNA replication centers where they affect viral DNA replication (11) (12) (13) . Thus, there is clear evidence that adenovirus infection has a substantial impact on the composition and function.....
    Document: nucleus are inhibited, and a number of viral nucleolar antigens accumulate in the nucleoli of infected cells (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) . Moreover, two cellular nucleolar antigens, UBF 1 and B23.1, have been shown to be sequestered into viral DNA replication centers where they affect viral DNA replication (11) (12) (13) . Thus, there is clear evidence that adenovirus infection has a substantial impact on the composition and function of the nucleolus. What is not clear is whether the sequestration of cellular nucleolar antigens is limited to a small number of proteins or widespread. In addition, it is unclear whether adenovirus primarily modulates the nucleolus for replicative advantage or whether the effects on the nucleolus are a side effect of cellular proteins being sequestered into virally induced structures.

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