Author: Pruitt, Hawley C.; Devine, Daniel J.; Samant, Rajeev S.
Title: Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination Document date: 2016_3_11
ID: k3vjqumq_7
Snippet: The first indication that NMI was involved in influencing breast cancer biology came with the discovery of its interaction with c-Myc, and BRCA1 forming a novel heterotrimeric protein complex. The presence of NMI in this complex led to the sequestration of c-Myc and a subsequent decrease in the expression of telomerase reverse transcriptase (hTERT). 9 Thus, NMI was shown to ameliorate one well-known cause of cellular immortalization-hTERT express.....
Document: The first indication that NMI was involved in influencing breast cancer biology came with the discovery of its interaction with c-Myc, and BRCA1 forming a novel heterotrimeric protein complex. The presence of NMI in this complex led to the sequestration of c-Myc and a subsequent decrease in the expression of telomerase reverse transcriptase (hTERT). 9 Thus, NMI was shown to ameliorate one well-known cause of cellular immortalization-hTERT expression. This observation is isolated, and many details of this mechanism remain unclear. However, a clearer role of NMI emerges when we consider its involvement in DNA damage repair.
Search related documents:
Co phrase search for related documents, hyperlinks ordered by date