Author: Braun, Elisabeth; Sauter, Daniel
Title: Furin-mediated protein processing in infectious diseases and cancer Document date: 2019_8_5
ID: k3m72uxw_10
Snippet: The physiological importance of furin is reflected by furin knock-out mice, which die at embryonic day 11 because of cardial ventral closure defects and hemodynamic insufficiency. 24 Similarly, endothelial cell-specific knock-out of furin results in cardiac malformation and death shortly after birth. 25 Even mutations in the cleavage site of a single furin target protein may have detrimental effects and result in genetic disorders such as haemoph.....
Document: The physiological importance of furin is reflected by furin knock-out mice, which die at embryonic day 11 because of cardial ventral closure defects and hemodynamic insufficiency. 24 Similarly, endothelial cell-specific knock-out of furin results in cardiac malformation and death shortly after birth. 25 Even mutations in the cleavage site of a single furin target protein may have detrimental effects and result in genetic disorders such as haemophilia B or X-linked hypohidrotic ectodermal dysplasia. 26, 27 Because of its pleiotropic effects, variations in furin expression levels and/or its enzymatic activity may have detrimental effects and promote the pathogenesis of a variety of disorders, including rheumatoid arthritis, amyloid dementia and cancer. 17
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