Selected article for: "detectable expression and protein expression"
Author: Rasmy, Hanaa; Mikhael, Nancy; Ismail, Somaia
Title: Interleukin-18 expression and the response to treatment in patients with psoriasis
  • Document date: 2011_9_2
    • ID: jppdl104_32
    Snippet: In the present study our patients with psoriasis showed significantly increased IL-18 expression in keratinocytes from psoriatic lesions before and after receiving medication, whether topical or systemic, in comparison to keratinocytes from non-lesional skin. This supports the concept of psoriasis as a T cell mediated autoimmune disease. Krueger [18] reported, in his study on a large series of skin biopsies, increased protein expression in lesion.....
    Document: In the present study our patients with psoriasis showed significantly increased IL-18 expression in keratinocytes from psoriatic lesions before and after receiving medication, whether topical or systemic, in comparison to keratinocytes from non-lesional skin. This supports the concept of psoriasis as a T cell mediated autoimmune disease. Krueger [18] reported, in his study on a large series of skin biopsies, increased protein expression in lesional as opposed to non-lesional skin samples. Other investigators stated that lesional skin might be the source of the elevated plasma levels of IL-18 [19] . In the present work quantitative PCR using mRNA taken from uninvolved skin revealed low but detectable levels of IL-18 mRNA expression. This finding is consistent with previous studies showing that human keratinocytes are capable of synthesizing low levels of IL-18 mRNA even under nonstimulated conditions [20] . Chang et al. [21] found that genes specifically modulated in uninvolved skin play a major role in triggering disease progression, and in being the first candidate for early disease diagnosis or development of new therapies. This finding could allow selection of the treatment regimen for individual patients.

    Search related documents:
    Co phrase search for related documents
    • autoimmune disease and disease progression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • autoimmune disease and human keratinocyte: 1
    • autoimmune disease and individual patient: 1
    • autoimmune disease and lesional skin: 1, 2, 3
    • autoimmune disease and low level: 1, 2, 3
    • autoimmune disease and major role: 1, 2, 3, 4, 5
    • autoimmune disease and mrna expression: 1, 2, 3, 4
    • detectable low level and low level: 1, 2, 3, 4, 5, 6
    • development early disease diagnosis and disease diagnosis: 1, 2, 3, 4, 5, 6
    • development early disease diagnosis and disease progression: 1, 2, 3
    • development early disease diagnosis and early disease diagnosis: 1, 2, 3, 4, 5, 6
    • disease diagnosis and early disease diagnosis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • disease diagnosis and individual patient: 1, 2, 3, 4, 5, 6, 7
    • disease diagnosis and large series: 1
    • disease diagnosis and lesional skin: 1
    • disease diagnosis and low level: 1, 2, 3, 4, 5, 6, 7
    • disease diagnosis and major role: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • disease diagnosis and mrna expression: 1, 2, 3, 4, 5, 6
    • disease progression and early disease diagnosis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25