Selected article for: "kg day and weight day"
Author: Bein, Thomas; Grasso, Salvatore; Moerer, Onnen; Quintel, Michael; Guerin, Claude; Deja, Maria; Brondani, Anita; Mehta, Sangeeta
Title: The standard of care of patients with ARDS: ventilatory settings and rescue therapies for refractory hypoxemia
  • Document date: 2016_4_4
    • ID: krpg9u1u_9
    Snippet: Low V T ventilation (6 ml/kg predicted body weight, PBW) reduces 28-day and total hospital mortality [8] , but PBW-based V T ignores the lung volume actually available for ventilation. The applied volume is only distributed to aerated regions, and the larger the non-aerated regions, the greater the associated hyperinflation (strain). The driving pressure for a given V T is responsible for opening lung areas which are collapsed at end-expiration. .....
    Document: Low V T ventilation (6 ml/kg predicted body weight, PBW) reduces 28-day and total hospital mortality [8] , but PBW-based V T ignores the lung volume actually available for ventilation. The applied volume is only distributed to aerated regions, and the larger the non-aerated regions, the greater the associated hyperinflation (strain). The driving pressure for a given V T is responsible for opening lung areas which are collapsed at end-expiration. A lower pressure will not reopen these areas and hypoxemia will worsen. The solution is to increase PEEP in order to reap the potential benefits of such a protective approach, especially in severe ARDS. This will also reduce the driving pressure required [9, 10] . It would allow more individualized settings based on physiologic measurements and considerations [11] [12] [13] .

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