Author: Bautista-Hernández, Luis Antonio; Gómez-Olivares, José Luis; Buentello-Volante, Beatriz; Bautista-de Lucio, Victor Manuel
Title: Fibroblasts: The Unknown Sentinels Eliciting Immune Responses Against Microorganisms Document date: 2017_8_19
ID: j4lfwdbh_9
Snippet: The recognition of PAMPs by TLRs can occur at the cell surface (TLR1, TLR2, TLR4, TLR5, and TLR6) and in intracellular vesicles (TLR3, TLR7, TLR8, and TLR9). TLRs play an important role in recognizing microbial components from bacteria, fungi, parasites, and viruses [11] . TRL1, TLR2, and TLR4 recognize bacterial cellular walls, and TLR2 forms heterodimer complexes with TLR1 or TLR6. TLR3 recognizes polyinosinic-polycytidylic acid (poly I:C) and .....
Document: The recognition of PAMPs by TLRs can occur at the cell surface (TLR1, TLR2, TLR4, TLR5, and TLR6) and in intracellular vesicles (TLR3, TLR7, TLR8, and TLR9). TLRs play an important role in recognizing microbial components from bacteria, fungi, parasites, and viruses [11] . TRL1, TLR2, and TLR4 recognize bacterial cellular walls, and TLR2 forms heterodimer complexes with TLR1 or TLR6. TLR3 recognizes polyinosinic-polycytidylic acid (poly I:C) and double-stranded viral ribonucleic acid (RNA). The fl agellin of gram-negative bacteria can be recognized by TLR5 and TLR7, while TLR8 recognizes single-stranded viral RNA and TLR9 identifi es viral and bacterial deoxyribonucleic acid (DNA) unmethylated CpG motifs [9, 10, 12] , and expression of TLR10 has been induced by exposure to Helicobacter pylori [13] .
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