Author: Zhu, Zhen-Hong; Song, Wen-Qi; Zhang, Chang-Qing; Yin, Ji-Min
Title: Dimethyloxaloylglycine increases bone repair capacity of adipose-derived stem cells in the treatment of osteonecrosis of the femoral head Document date: 2016_9_13
ID: kjvy2c2k_31
Snippet: However, the risks of gene transduction, such as tumorigenesis and permanent overexpression of the transduced gene, limited its clinical application (20) . To overcome these deficiencies, in the present study dimethyloxaloylglycine (DMOG), a cell permeable prolyl-4-hydroxylase inhibitor, was employed to enhance HIF-1α expression in MSCs in place of the HIF-1α gene transduction......
Document: However, the risks of gene transduction, such as tumorigenesis and permanent overexpression of the transduced gene, limited its clinical application (20) . To overcome these deficiencies, in the present study dimethyloxaloylglycine (DMOG), a cell permeable prolyl-4-hydroxylase inhibitor, was employed to enhance HIF-1α expression in MSCs in place of the HIF-1α gene transduction.
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