Author: McCreary, Erin K; Pogue, Jason M
Title: Coronavirus Disease 2019 Treatment: A Review of Early and Emerging Options Document date: 2020_3_23
ID: j0i9ozsz_11
Snippet: Although this development has been encouraging, supply issues in the United States and cardiovascular toxicity concerns limit the use of chloroquine. As an alternative, hydroxychloroquine, a compound that differs from chloroquine only by a single hydroxyl group, has garnered interest. Hydroxychloroquine is perceived as having better tolerability than chloroquine, which has led to long-term usage in rheumatological disorders. Historically, very li.....
Document: Although this development has been encouraging, supply issues in the United States and cardiovascular toxicity concerns limit the use of chloroquine. As an alternative, hydroxychloroquine, a compound that differs from chloroquine only by a single hydroxyl group, has garnered interest. Hydroxychloroquine is perceived as having better tolerability than chloroquine, which has led to long-term usage in rheumatological disorders. Historically, very limited data were published assessing the activity of hydroxychloroquine against coronaviruses. In 2006, Biot et al [17] assessed the comparative inhibitory activity of chloroquine and hydroxychloroquine against SARS-CoV-1 in Vero cells. The authors demonstrated that chloroquine had an approximately 5-fold increased potency (EC 50 of 6.5 ± 3.2 µM) compared with that of hydroxychloroquine (EC 50 of 34 ± 5 µM).
Search related documents:
Co phrase search for related documents- cardiovascular toxicity and long term: 1, 2
- chloroquine differ and hydroxychloroquine chloroquine: 1, 2
- hydroxychloroquine activity and inhibitory activity: 1, 2
- hydroxychloroquine activity and long term: 1, 2, 3, 4
- hydroxychloroquine chloroquine and inhibitory activity: 1, 2, 3, 4, 5
- hydroxychloroquine chloroquine and long term: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- hydroxychloroquine chloroquine and long term usage: 1, 2
- hydroxyl group and inhibitory activity: 1, 2, 3, 4, 5
- increase potency and long term: 1, 2
- inhibitory activity and long term: 1, 2, 3, 4, 5, 6, 7, 8
- inhibitory activity and long term usage: 1
Co phrase search for related documents, hyperlinks ordered by date