Author: Qingyang Xu; Shomesh Chaudhuri; Danying Xiao; Andrew W Lo
Title: Bayesian Adaptive Clinical Trials for Anti-Infective Therapeutics during Epidemic Outbreaks Document date: 2020_4_14
ID: 20hk99h4_50
Snippet: However, for the more fatal SARS and MERS (rows 9 and 12), the dynamic transmission model sets higher optimal Type I error and smaller sample size than 4. This is due to the U-shaped curve of optimal vs. , shown in Figure 1 . When the NPI reduces below a certain threshold, the optimal starts to increase. For highly fatal epidemics, when the government adopts NPIs to protect most of the susceptible population from infection, the regulatory priorit.....
Document: However, for the more fatal SARS and MERS (rows 9 and 12), the dynamic transmission model sets higher optimal Type I error and smaller sample size than 4. This is due to the U-shaped curve of optimal vs. , shown in Figure 1 . When the NPI reduces below a certain threshold, the optimal starts to increase. For highly fatal epidemics, when the government adopts NPIs to protect most of the susceptible population from infection, the regulatory priority should be to expedite potentially effective treatments that can help current patients since the loss of Type I error is much lower than that of the Type II error.
Search related documents:
Co phrase search for related documents- certain threshold and susceptible population: 1, 2, 3
- certain threshold and transmission model: 1, 2, 3, 4, 5
- current patient and sample size: 1, 2, 3, 4, 5, 6
- dynamic transmission model and sample size: 1, 2
- dynamic transmission model and susceptible population: 1, 2, 3, 4, 5, 6, 7
- dynamic transmission model and transmission model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- increase start and sample size: 1
- increase start and transmission model: 1
- infection susceptible population protect and susceptible population: 1, 2, 3
- infection susceptible population protect and susceptible population protect: 1, 2, 3
- potentially effective treatment and sample size: 1
- potentially effective treatment and transmission model: 1
Co phrase search for related documents, hyperlinks ordered by date