Author: Qingyang Xu; Shomesh Chaudhuri; Danying Xiao; Andrew W Lo
Title: Bayesian Adaptive Clinical Trials for Anti-Infective Therapeutics during Epidemic Outbreaks Document date: 2020_4_14
ID: 20hk99h4_51
Snippet: In addition, we investigate the impact of the timing and stringency of NPIs enforced by the government with different values of and . The results are summarized in Table 5 . We find that the optimal Type I error is larger for 3 weeks than 6 weeks. Therefore, if the government adopts well-enforced NPIs early on (such as the lockdown of Wuhan, China) to protect the susceptible population, this will reduce the loss associated with Type I error, lead.....
Document: In addition, we investigate the impact of the timing and stringency of NPIs enforced by the government with different values of and . The results are summarized in Table 5 . We find that the optimal Type I error is larger for 3 weeks than 6 weeks. Therefore, if the government adopts well-enforced NPIs early on (such as the lockdown of Wuhan, China) to protect the susceptible population, this will reduce the loss associated with Type I error, leading to expedited approvals of potentially effective therapeutics. Furthermore, the sooner an effective therapeutic is approved, the sooner will NPIs be lifted.
Search related documents:
Co phrase search for related documents- effective therapeutic and potentially effective therapeutic: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- effective therapeutic and susceptible population: 1
- enforce npi and stringency timing: 1
- expedite approval and Type error: 1, 2
Co phrase search for related documents, hyperlinks ordered by date