Author: Cobo, Fernando
Title: Application of Molecular Diagnostic Techniques for Viral Testing Document date: 2012_11_30
ID: jiy4cp4n_85
Snippet: Conventional PCR for detection of JC virus in the cerebrospinal fluid has replaced the brain biopsy for the diagnosis of presence of this virus in patients with leukoencephalopathy [67] . This technique had sensitivity that range 70-90% and a specificity that range 90-100% before the highly active antiretroviral therapy [68] . However, at the moment, the application of this therapy recovery the immune system, so the viral replication becomes to b.....
Document: Conventional PCR for detection of JC virus in the cerebrospinal fluid has replaced the brain biopsy for the diagnosis of presence of this virus in patients with leukoencephalopathy [67] . This technique had sensitivity that range 70-90% and a specificity that range 90-100% before the highly active antiretroviral therapy [68] . However, at the moment, the application of this therapy recovery the immune system, so the viral replication becomes to be decreased, being JC virus PCR negative in CSF. Currently, it has been developed a qualitative real-time PCR for JC virus detection in CSF.
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