Author: Pruitt, Hawley C.; Devine, Daniel J.; Samant, Rajeev S.
Title: Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination Document date: 2016_3_11
ID: k3vjqumq_31
Snippet: Another potential transcriptional regulator of NMI is Ets-1. The Ets family of transcription factors is highly conserved among species and has documented roles in physiologic and pathologic processes. 79 Ets-1 is an upstream regulator of NMI. When expressed in MCF-7 breast cancer cells, Ets-1 increased NMI mRNA and protein expression, as well as STAT1 expression. 80 Although the study suggests NMI has a role in Ets-1 related breast carcinogenesis.....
Document: Another potential transcriptional regulator of NMI is Ets-1. The Ets family of transcription factors is highly conserved among species and has documented roles in physiologic and pathologic processes. 79 Ets-1 is an upstream regulator of NMI. When expressed in MCF-7 breast cancer cells, Ets-1 increased NMI mRNA and protein expression, as well as STAT1 expression. 80 Although the study suggests NMI has a role in Ets-1 related breast carcinogenesis, it remains unclear whether that role is permissive or inhibitory.
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