Author: Kaul, Karen L.; Sabatini, Linda M.; Tsongalis, Gregory J.; Caliendo, Angela M.; Olsen, Randall J.; Ashwood, Edward R.; Bale, Sherri; Benirschke, Robert; Carlow, Dean; Funke, Birgit H.; Grody, Wayne W.; Hayden, Randall T.; Hegde, Madhuri; Lyon, Elaine; Murata, Kazunori; Pessin, Melissa; Press, Richard D.; Thomson, Richard B.
Title: The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care Document date: 2017_7_16
ID: jzwwses4_26
Snippet: BRAF belongs to a family of serine-threonine protein kinases that participate in signal transduction cascades involving RAS, RAF MEK, and ERK family members. This pathway is important in the regulation of normal cell proliferation and differentiation. 59 Activating mutations in BRAF can lead to increased proliferation and prolonged cell survival in a variety of tumor types. 60 Laboratories will typically test for BRAF mutations in low-grade gliom.....
Document: BRAF belongs to a family of serine-threonine protein kinases that participate in signal transduction cascades involving RAS, RAF MEK, and ERK family members. This pathway is important in the regulation of normal cell proliferation and differentiation. 59 Activating mutations in BRAF can lead to increased proliferation and prolonged cell survival in a variety of tumor types. 60 Laboratories will typically test for BRAF mutations in low-grade gliomas (for diagnosis), colorectal cancer (to establish the sporadic origin of MSI-H tumors and response to anti-EGFR therapy), hairy cell leukemia (for diagnosis), lung adenocarcinomas (to predict response to therapy), thyroid cancer (for preoperative detection of thyroid cancer in FNA samples and prognosis in papillary thyroid carcinoma), or melanoma (to predict response to BRAF kinase inhibitors).
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