Author: Hernandez, Nicholas; Melki, Isabelle; Jing, Huie; Habib, Tanwir; Huang, Susie S.Y.; Danielson, Jeffrey; Kula, Tomasz; Drutman, Scott; Belkaya, Serkan; Rattina, Vimel; Lorenzo-Diaz, Lazaro; Boulai, Anais; Rose, Yoann; Kitabayashi, Naoki; Rodero, Mathieu P.; Dumaine, Cecile; Blanche, Stéphane; Lebras, Marie-Noëlle; Leung, Man Chun; Mathew, Lisa Sara; Boisson, Bertrand; Zhang, Shen-Ying; Boisson-Dupuis, Stephanie; Giliani, Silvia; Chaussabel, Damien; Notarangelo, Luigi D.; Elledge, Stephen J.; Ciancanelli, Michael J.; Abel, Laurent; Zhang, Qian; Marr, Nico; Crow, Yanick J.; Su, Helen C.; Casanova, Jean-Laurent
Title: Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency Document date: 2018_10_1
ID: jqv0lyfx_28
Snippet: Standard immunological tests were performed. Serum levels of IgG, IgA, and IgM were unremarkable. T and natural killer lymphocyte count were conserved, whereas a modest B lymphocytosis was measured (Table S1 ). Lymphocyte proliferation was normal for PHA, tuberculin, and candidin (n > 50), but low in the presence of tetanus, CMV, and HSV antigens (n > 10; Table S2 ). T and B cell counts were within normal ranges. The patient was IgG seropositive.....
Document: Standard immunological tests were performed. Serum levels of IgG, IgA, and IgM were unremarkable. T and natural killer lymphocyte count were conserved, whereas a modest B lymphocytosis was measured (Table S1 ). Lymphocyte proliferation was normal for PHA, tuberculin, and candidin (n > 50), but low in the presence of tetanus, CMV, and HSV antigens (n > 10; Table S2 ). T and B cell counts were within normal ranges. The patient was IgG seropositive for tetanus, diphtheria, haemophilus, measles, mumps, rubella, and HBV (Ag HBs negative, anti-HBs positive, anti-HBc negative) following routine vaccination. She remained seronegative for HIV1/2, HAV, HCV, VZV, Parvovirus B19, EBV, CMV, and pneumococcus despite proper vaccination for the latter.
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