Title: The propeptide of preprosomatostatin mediates intracellular transport and secretion of alpha-globin from mammalian cells Document date: 1989_5_1
ID: kjid2e3q_4
Snippet: We are studying the processing of anglerfish prosomatostatin (proSRIF) in order to identify structural domains within peptide hormone precursors which might function in targeting to the regulated secretory pathway (41, 46) . Somatostatin is a 14-amino acid peptide hormone that is synthesized as part of a larger precursor, preproSRIF (13) ; it consists of a 25-amino acid signal peptide followed by a proregion of 82 residues. The mature hormone is .....
Document: We are studying the processing of anglerfish prosomatostatin (proSRIF) in order to identify structural domains within peptide hormone precursors which might function in targeting to the regulated secretory pathway (41, 46) . Somatostatin is a 14-amino acid peptide hormone that is synthesized as part of a larger precursor, preproSRIF (13) ; it consists of a 25-amino acid signal peptide followed by a proregion of 82 residues. The mature hormone is located at the carboxyl terminus of the propeptide and is preceded by a single pair of basic amino acids: ArgLys. These residues are a subset ofa hexapeptide domain (AlaProArgGluArgLys) which is conserved in all proSRIF species. Apart from endoproteolytic cleavage, the precursor undergoes no other posttranslational modifications.
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