Randomised controlled trial of rhinothermy for treatment of the common cold: a feasibility study

van de Hei, Susanne; McKinstry, Steven; Bardsley, George; Weatherall, Mark; Beasley, Richard; Fingleton, James

Participants who used Vitamin C returned the bottle for medicines reconciliation. 219 220 All participants were requested to complete a symptom diary every day for 10 days. The diary 221 comprised a daily modified Jackson score questionnaire and a box to tick when they first felt "a 222 lot better" compared to study entry. The mean change in modified Jackson score when 223 participants felt "a lot better" was used to estimate the MCID. 1. Assess the proportion of screened participants who were randomised into the trial. If a 248 minimum of 60 patients were approached, assuming a recruitment rate of 50% or less, an 249 achieved participation of 30 participants has 80% power, one sided alpha of 5% to rule out 250 a recruitment rate of less than 34%. Participant flow through the study is shown in Figure 2 . In all, 79 potential participants were 279 screened for eligibility and 30 participants were randomised. All participants completed their 280 visits between 12 May 2016 and 13 July 2016. Participants were predominantly young adults 281 who were non-smokers (Table 1) . 282 283