Author: Braun, Elisabeth; Sauter, Daniel
Title: Furin-mediated protein processing in infectious diseases and cancer Document date: 2019_8_5
ID: k3m72uxw_12_1
Snippet: tients suggests that the IFNc-furin feedback loop may be further boosted iatrogenically since radiotherapy increased furin expression in some patients. 38 In summary, aberrant furin activation promotes several steps of cancer development, including cell proliferation, vascularisation, metastasis and antitumor immunity. However, the relative contribution of individual furin substrates to tumor progression and the role of other proprotein convertas.....
Document: tients suggests that the IFNc-furin feedback loop may be further boosted iatrogenically since radiotherapy increased furin expression in some patients. 38 In summary, aberrant furin activation promotes several steps of cancer development, including cell proliferation, vascularisation, metastasis and antitumor immunity. However, the relative contribution of individual furin substrates to tumor progression and the role of other proprotein convertases remain largely unclear.
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