Atti del 52° Congresso Nazionale: Società Italiana di Igiene, Medicina Preventiva e Sanità Pubblica (SItI)

Overall, 6499 patients were enrolled, with a median age of 72 years (IQR: 57-81), a male:female ratio = 0.99:1 and a median HAI onset time of 15 days (IQR: 7-29). 50.0% of the patient had a Non-fatal McCabe score; 31.2% had an ultimately-fatal, 17.1% had a rapidly-fatal and 2.7% had an Unknown score. HAI prevalence resulted 15.5% in 2014, 16.27% in 2015, 13.24% in 2016 (I),13.73% in 2016 (II), 14.12% in 2018 and 11.22% in 2019 with a decreasing trend (p < 0.01). Despise antibiotic therapy prevalence varied very little over the years, resulting 46.2% overall the study period, the prevalence of use of carbapenems (J01DH) and fluoroquinolones (J01MA) decerased while penicillins plus beta-lactamase inhibitors (J01CR) increased (p < 0.01). Overall, bloodstream and low-respiratory tract infections were the most frequent HAI with a prevalence of 22.4% and 19.3% respectively. Staphylococcus aureus (12.4%) Staphylococcus epidermidis (12.0%) and Klebsiella pneumoniae (10.0%) were the most frequent microorganisms isolated in bloodstream infections. In the multivariate logistic regression analysis, ultimately or rapid Mc-Cabe score, surgery, hospitalization in intensive care unit, central line catheter use and urinary catheter use were associated with a higher risk of developing an HAI (p < 0.01).