Selected article for: "copy number and situ hybridization"
Author: Castrignano, Silvana Beres; Nagasse-Sugahara, Teresa Keico
Title: The metagenomic approach and causality in virology
  • Document date: 2015_4_1
    • ID: ivu4erpq_7
    Snippet: On the other hand, according to the molecular guidelines of Fredericks & Relman 9 for establishing microbial disease causation, there is no need to isolate a virus or inoculate it in a host. These guidelines are based on the identification of the microbial genome using in situ hybridization in tissue samples with pathological changes and on the analysis of the copy number of pathogen-associated nucleic acid sequences in tissue samples with or wit.....
    Document: On the other hand, according to the molecular guidelines of Fredericks & Relman 9 for establishing microbial disease causation, there is no need to isolate a virus or inoculate it in a host. These guidelines are based on the identification of the microbial genome using in situ hybridization in tissue samples with pathological changes and on the analysis of the copy number of pathogen-associated nucleic acid sequences in tissue samples with or without lesions during several phases of the disease, including the period before disease onset.

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