Author: Zhou, Ping; Zhai, Shanli; Zhou, Xiang; Lin, Ping; Jiang, Tengfei; Hu, Xueying; Jiang, Yunbo; Wu, Bin; Zhang, Qingde; Xu, Xuewen; Li, Jin-ping; Liu, Bang
Title: Molecular Characterization of Transcriptome-wide Interactions between Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and Porcine Alveolar Macrophages in vivo Document date: 2011_8_7
ID: js7l86fh_25
Snippet: Nine genes (S100A6, MARCKS, CACYBP, CCT6A, ARHE, CCT3, PTPN4, CCT7, and TWF1) related to actin and tubulin cytoskeleton organization were upregulated and three (RASSF8, ELMO1, and KIF11) were downregulated (Table 3 ). In addition, several exocytosis related genes (RSAD2, GSK3B, LMAN2L, EXOC2, SELS, COPZ2, SEC31L2, and SEC8L1) were differentially expressed in PAMs after HP-PRRSV infection (Table 3) . RSAD2, encoding an IFN-induced protein which in.....
Document: Nine genes (S100A6, MARCKS, CACYBP, CCT6A, ARHE, CCT3, PTPN4, CCT7, and TWF1) related to actin and tubulin cytoskeleton organization were upregulated and three (RASSF8, ELMO1, and KIF11) were downregulated (Table 3 ). In addition, several exocytosis related genes (RSAD2, GSK3B, LMAN2L, EXOC2, SELS, COPZ2, SEC31L2, and SEC8L1) were differentially expressed in PAMs after HP-PRRSV infection (Table 3) . RSAD2, encoding an IFN-induced protein which inhibits influenza A virus release from the plasma membrane of infected cells by affecting the formation of lipid rafts [28] , was upregulated significantly. Vesicle trafficking between the Golgi apparatus and ER seemed to be restricted, because COPZ2, a member of the COPI coat which helps vesicles transport proteins from the cis end of the Golgi complex back to the rough ER [29] , and SEC31L2, a component of the COPII vesicle coat that mediates vesicular traffic from the rough ER to the Golgi apparatus [30] , were both downregulated.
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