Author: Hernandez, Nicholas; Melki, Isabelle; Jing, Huie; Habib, Tanwir; Huang, Susie S.Y.; Danielson, Jeffrey; Kula, Tomasz; Drutman, Scott; Belkaya, Serkan; Rattina, Vimel; Lorenzo-Diaz, Lazaro; Boulai, Anais; Rose, Yoann; Kitabayashi, Naoki; Rodero, Mathieu P.; Dumaine, Cecile; Blanche, Stéphane; Lebras, Marie-Noëlle; Leung, Man Chun; Mathew, Lisa Sara; Boisson, Bertrand; Zhang, Shen-Ying; Boisson-Dupuis, Stephanie; Giliani, Silvia; Chaussabel, Damien; Notarangelo, Luigi D.; Elledge, Stephen J.; Ciancanelli, Michael J.; Abel, Laurent; Zhang, Qian; Marr, Nico; Crow, Yanick J.; Su, Helen C.; Casanova, Jean-Laurent
Title: Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency Document date: 2018_10_1
ID: jqv0lyfx_27
Snippet: At 23 mo of age, she was admitted to the PICU with a severe influenza A infection resulting in ARDS requiring mechanical ventilation for 6 d. Because increased oxygen was required with continuous positive airway pressure (FiO 2 100%), she was intubated. She developed severe ARDS, with bilateral infiltrates on chest radiography. She was placed under mechanical ventilation in a volume support mode, with a frequency of 35 per minute and 100% FiO 2 ......
Document: At 23 mo of age, she was admitted to the PICU with a severe influenza A infection resulting in ARDS requiring mechanical ventilation for 6 d. Because increased oxygen was required with continuous positive airway pressure (FiO 2 100%), she was intubated. She developed severe ARDS, with bilateral infiltrates on chest radiography. She was placed under mechanical ventilation in a volume support mode, with a frequency of 35 per minute and 100% FiO 2 . All bacteriological and viral sputum cultures were negative, except IAV. She was administered salbutamol, ipratropium bromide, ketamine, theophylline, magnesium sulfate, ceftriaxone, and oseltamivir. The oseltamivir treatment was stopped after 5 d. On the third day, bilateral parotidis and cervical adenitis appeared and were treated by amoxicillin and clavulanic acid. She was discharged from the PICU after 8 d, and her condition improved enough to be discharged after 22 d of hospitalization.
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