Author: Ross D. Overacker; Somdev Banerjee; George F. Neuhaus; Selena Milicevic Sephton; Alexander Herrmann; James A. Strother; Ruth Brack-Werner; Paul R. Blakemore; Sandra Loesgen
Title: Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline Document date: 2019_1_23
ID: m2zw8eq4_6
Snippet: The significant difference in antiviral activity of these two regioisomers (B#24 and B#59) hints 155 towards a highly specific and selective mode of inhibition. The corresponding carbamate 156 derivatives of deoxy-8-azaBINOLs, B#43 and B#60, both showed moderate antiviral activity 157 against all three viral strains but with smaller selectivity indices. Again, neither of the 2-deoxy-158 8,8´-diazaBINOL derivatives, B#57 or B#58, showed any antiv.....
Document: The significant difference in antiviral activity of these two regioisomers (B#24 and B#59) hints 155 towards a highly specific and selective mode of inhibition. The corresponding carbamate 156 derivatives of deoxy-8-azaBINOLs, B#43 and B#60, both showed moderate antiviral activity 157 against all three viral strains but with smaller selectivity indices. Again, neither of the 2-deoxy-158 8,8´-diazaBINOL derivatives, B#57 or B#58, showed any antiviral activity at concentrations up 159 to 200 µM. 160
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