Author: Braun, Elisabeth; Sauter, Daniel
Title: Furin-mediated protein processing in infectious diseases and cancer Document date: 2019_8_5
ID: k3m72uxw_29
Snippet: While furin plays a key role in activating envelope glycoproteins of a variety of viruses, its activity is also exploited for the cleavage of other viral proteins. One example is the cleavage of the L2 protein of papillomaviruses. 79 Together with the major capsid protein L1, this minor capsid protein builds the viral capsid. The furin cleavage site is located close to the N terminus of L2 and highly conserved among different human papillomavirus.....
Document: While furin plays a key role in activating envelope glycoproteins of a variety of viruses, its activity is also exploited for the cleavage of other viral proteins. One example is the cleavage of the L2 protein of papillomaviruses. 79 Together with the major capsid protein L1, this minor capsid protein builds the viral capsid. The furin cleavage site is located close to the N terminus of L2 and highly conserved among different human papillomavirus (HPV) strains. 80 Cleavage is not required for virus assembly or release, but essential for infection of new target cells. For example, LoVo and CHO cells lacking furin expression are completely resistant to infection with pseudoviruses of HPV16, 79, 80 which is one of the high-risk HPV types causing cervical cancer.
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