Author: Casanova, Victor; Sousa, Filipa H; Stevens, Craig; Barlow, Peter G
Title: Antiviral therapeutic approaches for human rhinovirus infections Document date: 2018_6_12
ID: kl7holv4_25
Snippet: Polyinosinic-polycytidylic acid, commonly referred to as Poly I:C, is a dsRNA structure that mimics intermediates generated during viral replication. When sensed by TLR-3 or cytoplasmic RLR sensors (MAD5 and RIG-I), Poly I:C induces a strong interferon response, and prophylactic administration of Poly I:C in vitro or in vivo can enhance protection against a number of viral infections, including several strains of RV [118, 119, 120, 121] ......
Document: Polyinosinic-polycytidylic acid, commonly referred to as Poly I:C, is a dsRNA structure that mimics intermediates generated during viral replication. When sensed by TLR-3 or cytoplasmic RLR sensors (MAD5 and RIG-I), Poly I:C induces a strong interferon response, and prophylactic administration of Poly I:C in vitro or in vivo can enhance protection against a number of viral infections, including several strains of RV [118, 119, 120, 121] .
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