Author: Na, Woonsung; Yeom, Minjoo; Choi, Il-Kyu; Yook, Heejun; Song, Daesub
Title: Animal models for dengue vaccine development and testing Document date: 2017_7_26
ID: jlmuo37x_4
Snippet: DENV-susceptible mouse models have been developed by genetically modifying the immune system to maintain the infected state. However, this model has limitations related to the immune response, and it is not applicable to all DENV serotypes. At present, there are no experimental models that reflect the pathological characteristics and clinical symptoms in humans, in part because DENV only infects apes and people. The use of primate species as expe.....
Document: DENV-susceptible mouse models have been developed by genetically modifying the immune system to maintain the infected state. However, this model has limitations related to the immune response, and it is not applicable to all DENV serotypes. At present, there are no experimental models that reflect the pathological characteristics and clinical symptoms in humans, in part because DENV only infects apes and people. The use of primate species as experimental models also has limitations, including the high cost and challenges of managing them, and such models are not appropriate in certain situations, since they present viremia without clinical symptoms.
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