Author: de Sousa, Jorge Rodrigues; Da Costa Vasconcelos, Pedro Fernando; Quaresma, Juarez Antonio Simões
Title: Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases Document date: 2019_8_22
ID: jq9gcjsa_11_2
Snippet: g triggered by receptor-cytokine binding influences concomitant activation and phosphorylation of JAK1, JAK2, STAT1, and STAT2, as well as the formation of STAT/IRF complexes that primarily activate genes associated with the production of inflammatory mediators responsible for inhibiting viral replication (Figure 4) . [201] [202] [203] Assuming that negative regulation coupled to non-structural proteins of flavivirus or HCV is crucial for viral s.....
Document: g triggered by receptor-cytokine binding influences concomitant activation and phosphorylation of JAK1, JAK2, STAT1, and STAT2, as well as the formation of STAT/IRF complexes that primarily activate genes associated with the production of inflammatory mediators responsible for inhibiting viral replication (Figure 4) . [201] [202] [203] Assuming that negative regulation coupled to non-structural proteins of flavivirus or HCV is crucial for viral survival, the immune leakage, in this case, mainly inhibits intracellular signaling pathways (Figure 4 ).
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