Author: Zhao, Jingxian; Zhao, Jincun; Fett, Craig; Trandem, Kathryn; Fleming, Erica; Perlman, Stanley
Title: IFN-?– and IL-10–expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis Document date: 2011_8_1
ID: k751ryv4_2
Snippet: The neurotropic rJ2.2 strain of mouse hepatitis virus, a coronavirus, causes mild acute encephalitis and chronic demyelination (Fleming et al., 1986) . We previously showed that T reg cells have a critical role in diminishing immunopathological disease in rJ2.2-infected mice. Thus, adoptive transfer of T reg cells from naive spleens (natural T reg cells) into infected mice decreased weight loss, clinical scores, and demyelination (Trandem et al.,.....
Document: The neurotropic rJ2.2 strain of mouse hepatitis virus, a coronavirus, causes mild acute encephalitis and chronic demyelination (Fleming et al., 1986) . We previously showed that T reg cells have a critical role in diminishing immunopathological disease in rJ2.2-infected mice. Thus, adoptive transfer of T reg cells from naive spleens (natural T reg cells) into infected mice decreased weight loss, clinical scores, and demyelination (Trandem et al., 2010) . However, whether any of these T reg cells are virus specific and whether virus-specific T reg cells are immunosuppressive in a cognate epitope-dependent manner are not known.
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