Author: Harlan Barker; Seppo Parkkila
Title: Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2 Document date: 2020_4_13
ID: 08vsaov7_23
Snippet: The respiratory tract is the main target region that is affected by COVID-19 infection. Bulk RNA-Seq data from lung specimens showed low expression levels for ACE2 ( Fig. 1 ). Therefore, we performed an analysis of single cell RNA-Seq using a mouse tracheal dataset, representing a more proximal segment of the respiratory tract. Figure 3 shows the expression of ACE2 mRNA in identified cell types. The highest number of ACE2-positive cells included .....
Document: The respiratory tract is the main target region that is affected by COVID-19 infection. Bulk RNA-Seq data from lung specimens showed low expression levels for ACE2 ( Fig. 1 ). Therefore, we performed an analysis of single cell RNA-Seq using a mouse tracheal dataset, representing a more proximal segment of the respiratory tract. Figure 3 shows the expression of ACE2 mRNA in identified cell types. The highest number of ACE2-positive cells included the goblet cells, ciliary epithelial cells, endothelial cells, and type I pneumocytes (AT1 cells). There were also sporadic positive cells in the club cell category.
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