Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2

Harlan Barker; Seppo Parkkila

Notably, there was no clear sex-specific trend pointing to one direction in all these cases. ACE mRNA expression levels in all studied tissues sorted according to subjects´ gender are shown in Supplementary Table 2 . The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.13.038752 doi: bioRxiv preprint terminal ileum), FOXA1 (cervix, colon, terminal ileum), HNF4A (colon, terminal ileum), FOXA2 (colon, kidney), NR2F6 (colon, kidney, terminal ileum), and SOX11 (kidney). In addition, two of the TFs are highly negatively correlated with ACE2 expression DUX4 (kidney) and FOXA1 (kidney). Full prediction results are included as Supplementary Table 3 The lung-specific transcript TSS aligns with the p3@ACE2 FANTOM5 dataset CAGE peak, which indicates that the expression of this transcript is much lower than the intestinal transcript, which corresponds with p1@ACE2 and p2@ACE2 FANTOM5 CAGE peaks. Common between the two tissue-specific transcripts, are predictions for CDX2 and HNF-family transcription factors.