Author: Bein, Thomas; Grasso, Salvatore; Moerer, Onnen; Quintel, Michael; Guerin, Claude; Deja, Maria; Brondani, Anita; Mehta, Sangeeta
Title: The standard of care of patients with ARDS: ventilatory settings and rescue therapies for refractory hypoxemia Document date: 2016_4_4
ID: krpg9u1u_6
Snippet: Hypoxemia and tissue hypoxia could be detected by PaO 2 , SaO 2 , serum lactate, and central venous oxygen saturation (SvO 2 ), which are global measurements, and the extent to which these flow/volume-average-weighted measurements reflect organ hypoxia remains unknown. In clinical practice the definition of "hypoxemia" is often based on one or more of these global values, and currently no parameter for the precise assessment of tissue hypoxia in .....
Document: Hypoxemia and tissue hypoxia could be detected by PaO 2 , SaO 2 , serum lactate, and central venous oxygen saturation (SvO 2 ), which are global measurements, and the extent to which these flow/volume-average-weighted measurements reflect organ hypoxia remains unknown. In clinical practice the definition of "hypoxemia" is often based on one or more of these global values, and currently no parameter for the precise assessment of tissue hypoxia in the individual patient is available. Since inadequate tissue oxygenation as well as excessive oxygen administration (with expression of oxygen reactive species) can both be harmful [7] , a careful balance based on precise control of arterial oxygenation including the acceptance of a "safe" threshold may avoid deleterious hypoxia as well as hyperoxia-associated injury. It remains to be evaluated in further studies whether selected biomarkers may help identify tissue hypoxia in the individual patient.
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