Author: Braun, Elisabeth; Sauter, Daniel
Title: Furin-mediated protein processing in infectious diseases and cancer Document date: 2019_8_5
ID: k3m72uxw_27
Snippet: The ratio of mature to immature prM depends on a variety of factors, including the producer cell type and the flavivirus species. For example, dengue viruses are known to release high amounts of immature or partially mature viruses, most likely because of a conserved acidic residue within the furin recognition site 78 (Table 2) . Importantly, the content of prM in viral particles also affects antibody recognition and consequently antibody-depende.....
Document: The ratio of mature to immature prM depends on a variety of factors, including the producer cell type and the flavivirus species. For example, dengue viruses are known to release high amounts of immature or partially mature viruses, most likely because of a conserved acidic residue within the furin recognition site 78 (Table 2) . Importantly, the content of prM in viral particles also affects antibody recognition and consequently antibody-dependent enhancement of dengue virus infection. 77 Thus, furin-mediated protein processing may once again markedly affect the outcome of infection.
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