Author: Peri, Sateesh; Kulkarni, Asmita; Feyertag, Felix; Berninsone, Patricia M; Alvarez-Ponce, David
Title: Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc Document date: 2017_12_30
ID: k596omcy_10
Snippet: Given the biological and biomedical relevance of Neu5Gc, it is important to know what animals have the ability to synthesize it. Knowing the exact lineages in which CMAH has been inactivated or lost will allow scientists to identify lineages that may have experimented changes similar to those experienced by humans, and will have implications for human nutrition and xenotransplantation. However, to date all studies of CMAH evolution have been rest.....
Document: Given the biological and biomedical relevance of Neu5Gc, it is important to know what animals have the ability to synthesize it. Knowing the exact lineages in which CMAH has been inactivated or lost will allow scientists to identify lineages that may have experimented changes similar to those experienced by humans, and will have implications for human nutrition and xenotransplantation. However, to date all studies of CMAH evolution have been restricted to specific organisms or groups of organisms. Here, we conduct the first comprehensive analysis of the evolution of CMAH. For that purpose, we analyzed all available genomic data in the National Center for Biotechnology Information (NCBI) databases, and the genomes of 323 deuterostomes. We found that the gene has been lost or inactivated at least 31 times during deuterostome evolution.
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