Author: Braun, Elisabeth; Sauter, Daniel
Title: Furin-mediated protein processing in infectious diseases and cancer Document date: 2019_8_5
ID: k3m72uxw_46
Snippet: One major challenge is the redundancy of furin with related proprotein convertases that also recognise polybasic cleavage sites. On the one hand, selective inhibition of furin may be beneficial as it limits unwanted side effects due to inhibition of other PCSKs. On the other hand, treatment of some diseases may require the simultaneous inhibition of several PCSKs to efficiently block pathological substrate conversion. To advance current approache.....
Document: One major challenge is the redundancy of furin with related proprotein convertases that also recognise polybasic cleavage sites. On the one hand, selective inhibition of furin may be beneficial as it limits unwanted side effects due to inhibition of other PCSKs. On the other hand, treatment of some diseases may require the simultaneous inhibition of several PCSKs to efficiently block pathological substrate conversion. To advance current approaches, a better understanding of the relative contribution of individual PCSKs to (nonphysiological) proteolytic protein processing is urgently needed. Therapeutic intervention needs to specifically target the convertase(s) that drive disease progression. Currently, the most promising approaches for selective inhibition are shRNAmediated silencing and nanobodies as they show no or only little off-target effects.
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