Author: Peri, Sateesh; Kulkarni, Asmita; Feyertag, Felix; Berninsone, Patricia M; Alvarez-Ponce, David
Title: Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc Document date: 2017_12_30
ID: k596omcy_49
Snippet: The NCBI Genome database contains the genomes of 14 members of the taxon Ruminantia (ten bovids, two giraffids, and two cervids). All bovid and giraffid species represented in the database contain a putatively functional CMAH gene, consistent with the high levels of Neu5Gc reported in beef (Samraj et al. 2015) . Among cervids, CMAH was present in the European roe deer (Capreolus capreolus), but not in the white-tailed deer (O. virginianus), indic.....
Document: The NCBI Genome database contains the genomes of 14 members of the taxon Ruminantia (ten bovids, two giraffids, and two cervids). All bovid and giraffid species represented in the database contain a putatively functional CMAH gene, consistent with the high levels of Neu5Gc reported in beef (Samraj et al. 2015) . Among cervids, CMAH was present in the European roe deer (Capreolus capreolus), but not in the white-tailed deer (O. virginianus), indicating that the gene was lost specifically in the O. virginianus lineage. Of note, gangliosides isolated from antlers of sika deer (Cervus nippon) have been shown to contain both Neu5Ac and Neu5Gc (Jhon et al. 1999) .
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