Author: William Rodriguez; Aman Srivastav; Mandy Muller
Title: C19ORF66 broadly escapes viral-induced endonuclease cleavage and restricts Kaposi’s Sarcoma Associated Herpesvirus (KSHV) Document date: 2018_12_26
ID: 5a4i8v59_15
Snippet: Furthermore, the transcript for C19ORF66 appeared in our comparative RNA-seq as the top 156 escapee in all the replicates and with all the endonucleases tested. We first evaluated whether 157 this transcript contained a putative SRE-like element in its 3'UTR by testing whether it could 158 protect the GFP mRNA, which is normally susceptible to viral endonuclease cleavage. We fused 159 the C19ORF66 3' UTR to GFP (C19-3'UTR) and found that it was s.....
Document: Furthermore, the transcript for C19ORF66 appeared in our comparative RNA-seq as the top 156 escapee in all the replicates and with all the endonucleases tested. We first evaluated whether 157 this transcript contained a putative SRE-like element in its 3'UTR by testing whether it could 158 protect the GFP mRNA, which is normally susceptible to viral endonuclease cleavage. We fused 159 the C19ORF66 3' UTR to GFP (C19-3'UTR) and found that it was sufficient to confer protection 160 from SOX and other viral endonucleases in transfected 293T cells (Fig. 3A) . Thus, similar to 161 All rights reserved. No reuse allowed without permission.
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