Author: William Rodriguez; Aman Srivastav; Mandy Muller
Title: C19ORF66 broadly escapes viral-induced endonuclease cleavage and restricts Kaposi’s Sarcoma Associated Herpesvirus (KSHV) Document date: 2018_12_26
ID: 5a4i8v59_4
Snippet: and were shown to protect against an array of viral -but not host -RNAses. Furthermore, while 56 little sequence homology was detected among these SREs, we showed that they share 57 similarity in their secondary structure; reinforcing the idea the SRE may function as a platform to 58 recruit a protective protein complex as previously observed (19) (20) (21) . Functionally, while the 59 beneficial role of IL-6 for KSHV during infection is well doc.....
Document: and were shown to protect against an array of viral -but not host -RNAses. Furthermore, while 56 little sequence homology was detected among these SREs, we showed that they share 57 similarity in their secondary structure; reinforcing the idea the SRE may function as a platform to 58 recruit a protective protein complex as previously observed (19) (20) (21) . Functionally, while the 59 beneficial role of IL-6 for KSHV during infection is well documented (25-33), the role of 60 GADD45B is still unclear. In fact, GADD45B is repressed during KSHV latency (34) and 61 GADD45B known pro-apoptotic roles may indicate that this transcript escapes to participate in 62 an anti-viral response to host shutoff. 63
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