Author: Brabb, Thea; von Dassow, Peter; Ordonez, Nadia; Schnabel, Bryan; Duke, Blythe; Goverman, Joan
Title: In Situ Tolerance within the Central Nervous System as a Mechanism for Preventing Autoimmunity Document date: 2000_9_18
ID: kcygxo7h_17
Snippet: Our analysis also revealed that the ratio of CD8 Ï© /CD4 Ï© T cells is more than twofold higher in the CNS than in the spleen in nontransgenic mice (data not shown). The basis for this CD8 Ï© enrichment in the CNS is not clear; however, it may reflect the fact that a higher percentage of CD44 high T cells are found in the CD8 Ï© peripheral T cell subset compared with the CD4 Ï© peripheral T cell subset (28 Ï® 3.5% versus 19 Ï® 3.9%, respectively,.....
Document: Our analysis also revealed that the ratio of CD8 Ï© /CD4 Ï© T cells is more than twofold higher in the CNS than in the spleen in nontransgenic mice (data not shown). The basis for this CD8 Ï© enrichment in the CNS is not clear; however, it may reflect the fact that a higher percentage of CD44 high T cells are found in the CD8 Ï© peripheral T cell subset compared with the CD4 Ï© peripheral T cell subset (28 Ï® 3.5% versus 19 Ï® 3.9%, respectively, n Ï 4) in wild-type mice.
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