Selected article for: "detect gene and gene detect"
Author: Peri, Sateesh; Kulkarni, Asmita; Feyertag, Felix; Berninsone, Patricia M; Alvarez-Ponce, David
Title: Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc
  • Document date: 2017_12_30
    • ID: k596omcy_57
    Snippet: Due to the incompleteness of all available deuterostome genome assemblies (Chain et al. 2009 ), 41 of the coding sequences of putatively functional CMAH genes identified in our study have some unsequenced fraction (typically, one coding exon is unsequenced; supplementary table S2 and data sets S1-S3, Supplementary Material online). It is possible that some of these unsequenced regions may contain pseudogenization signatures (premature stop codons.....
    Document: Due to the incompleteness of all available deuterostome genome assemblies (Chain et al. 2009 ), 41 of the coding sequences of putatively functional CMAH genes identified in our study have some unsequenced fraction (typically, one coding exon is unsequenced; supplementary table S2 and data sets S1-S3, Supplementary Material online). It is possible that some of these unsequenced regions may contain pseudogenization signatures (premature stop codons or frameshift mutations). In addition, our study has not considered the CMAH promoter. Therefore, it is possible that some of the CMAH homologs classified as "putatively functional" in our study might actually be pseudogenes. Finally, for most species only one genome is available, making it impossible to detect polymorphic variants of the CMAH gene.

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