Author: Casanova, Victor; Sousa, Filipa H; Stevens, Craig; Barlow, Peter G
Title: Antiviral therapeutic approaches for human rhinovirus infections Document date: 2018_6_12
ID: kl7holv4_14
Snippet: The antimicrobial properties of cathelicidins have been attributed to their highly cationic charge, which allows for the interaction with negatively charged bacterial and viral membranes leading to the formation of pores, and their hydrophobicity which helps the integration of the peptides into the microbial membranes. Cathelicidins have shown potent antiviral activity against a number of viruses (reviewed in [70] ) but the exact mechanism of act.....
Document: The antimicrobial properties of cathelicidins have been attributed to their highly cationic charge, which allows for the interaction with negatively charged bacterial and viral membranes leading to the formation of pores, and their hydrophobicity which helps the integration of the peptides into the microbial membranes. Cathelicidins have shown potent antiviral activity against a number of viruses (reviewed in [70] ) but the exact mechanism of action is still not fully elucidated. It is clear that the underlying antiviral mechanism of cathelicidins appears to be partly due to direct effects on the virus envelope, and this has been extensively shown in in vitro studies. Both LL-37, and the murine cathelicidin mCRAMP, have shown the ability to damage the viral envelope of vaccinia virus, influenza A virus (IAV) and HSV [77, 78, 79, 80] . LL-37 has also been shown to target viral envelope proteins inhibiting dengue virus entry into host cells [81] .
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