Selected article for: "amino acid and ancestral branch"
Author: Joana Damas; Graham M. Hughes; Kathleen C. Keough; Corrie A. Painter; Nicole S. Persky; Marco Corbo; Michael Hiller; Klaus-Peter Koepfli; Andreas R. Pfenning; Huabin Zhao; Diane P. Genereux; Ross Swofford; Katherine S. Pollard; Oliver A. Ryder; Martin T. Nweeia; Kerstin Lindblad-Toh; Emma C. Teeling; Elinor K. Karlsson; Harris A. Lewin
Title: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates
  • Document date: 2020_4_18
    • ID: 6ne76rh1_28
    Snippet: Given pervasive signatures of adaptive evolution in ACE2 across mammals, we next sought to test if any mammalian lineages are evolving particularly rapidly compared to the others. CODEML branch-site tests identified positive selection in both the ancestral Chiroptera branch (1 amino acid, ⍵=26.7, LRT= 4.22, p=0.039) and ancestral Cetartiodactyla branch (2 amino acids, ⍵=10.38, LRT= 7.89, p=0.004, Dataset S4.3) using 64 mammals. These residues.....
    Document: Given pervasive signatures of adaptive evolution in ACE2 across mammals, we next sought to test if any mammalian lineages are evolving particularly rapidly compared to the others. CODEML branch-site tests identified positive selection in both the ancestral Chiroptera branch (1 amino acid, ⍵=26.7, LRT= 4.22, p=0.039) and ancestral Cetartiodactyla branch (2 amino acids, ⍵=10.38, LRT= 7.89, p=0.004, Dataset S4.3) using 64 mammals. These residues did not correspond to known viral binding sites. We found no evidence for lineage-specific positive selection in the ancestral primate, rodent or carnivore lineages.

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