Author: Joana Damas; Graham M. Hughes; Kathleen C. Keough; Corrie A. Painter; Nicole S. Persky; Marco Corbo; Michael Hiller; Klaus-Peter Koepfli; Andreas R. Pfenning; Huabin Zhao; Diane P. Genereux; Ross Swofford; Katherine S. Pollard; Oliver A. Ryder; Martin T. Nweeia; Kerstin Lindblad-Toh; Emma C. Teeling; Elinor K. Karlsson; Harris A. Lewin
Title: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates Document date: 2020_4_18
ID: 6ne76rh1_30
Snippet: Positive selection in SARS-CoV-2 S protein . Positive selection was found using CODEML at sites L455, E484, F490 and S494 in the SARS-CoV-2 S sequence (âµ=1.15, LRT=116.7, p<0.001); however this signal was not particularly high, possibly due to the small sample size (N=8). All of these sites lie within or near the ACE2 SARS-CoV-2 S RBD binding sites ( Fig. 3 ) (38) ......
Document: Positive selection in SARS-CoV-2 S protein . Positive selection was found using CODEML at sites L455, E484, F490 and S494 in the SARS-CoV-2 S sequence (âµ=1.15, LRT=116.7, p<0.001); however this signal was not particularly high, possibly due to the small sample size (N=8). All of these sites lie within or near the ACE2 SARS-CoV-2 S RBD binding sites ( Fig. 3 ) (38) .
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