Title: Atti del 52° Congresso Nazionale: Società Italiana di Igiene, Medicina Preventiva e Sanità Pubblica (SItI) Document date: 2019_10_15
ID: jkke8ije_492
Snippet: An explanatory serum PFOA concentration of 30 ng/mL was chosen as reference, corresponding to a 7% increase in total cholesterol and a consequent increase in cardiovascular risk in adults over 40 years (EFSA December 2018 Scientific Opinion:BMDL5: 9.4 ng/mL). A baseline serum PFOA concentration of 46 ng/mL was considered (taking the median value measured among the participants to the Regional Health Surveillance Plan) to describe the substance cl.....
Document: An explanatory serum PFOA concentration of 30 ng/mL was chosen as reference, corresponding to a 7% increase in total cholesterol and a consequent increase in cardiovascular risk in adults over 40 years (EFSA December 2018 Scientific Opinion:BMDL5: 9.4 ng/mL). A baseline serum PFOA concentration of 46 ng/mL was considered (taking the median value measured among the participants to the Regional Health Surveillance Plan) to describe the substance clearance in response to different realistic scenarios of contamination of drinking water and raw food. A simplified one-compartment pharmacokinetic model, was used (half-life 2.3 years, distribution volume 0.17 ml/kg body weight, lactating women), according to USEPA 2016.
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