Dimethyloxaloylglycine increases bone repair capacity of adipose-derived stem cells in the treatment of osteonecrosis of the femoral head

Zhu, Zhen-Hong; Song, Wen-Qi; Zhang, Chang-Qing; Yin, Ji-Min

Bone regeneration in the necrotic area of each group was also evaluated using H&E staining. In Group I, there were numerous fat cells and rare trabecular tissue in the necrotic area, and numerous empty lacunae distributed along the trabeculae (Fig. 3A) . In Group II, there was less granulation tissue and fewer fat cells in the necrotic area, and some empty lacunae were observed (Fig. 3B) . In Group III, there was some disordered trabecular tissue in the necrotic area, which was obviously more than in Group II (Fig. 3C) . In Group IV, there was substantial trabecular tissue, and large osteocytes were distributed along the trabeculae (Fig. 3D) . Histomorphometric analysis confirmed that new bone in Group IV was more than that of other three groups, which was consistent with the micro-CT data (P<0.05; Fig. 3E ).