Selected article for: "DNA rna and nucleic acid"
Author: Mouzakis, Kathryn D.; Lang, Andrew L.; Vander Meulen, Kirk A.; Easterday, Preston D.; Butcher, Samuel E.
Title: HIV-1 frameshift efficiency is primarily determined by the stability of base pairs positioned at the mRNA entrance channel of the ribosome
  • Document date: 2012_12_15
    • ID: ix8du1er_35
    Snippet: In this work, we report a strong correlation between the thermodynamic stability of the first 3-4 bp at the base of the stem-loop and frameshift efficiency in HIV-1. We therefore hypothesize that the frameshift mechanism involves a thermodynamic block to translocation, determined by the local stability of base pairs positioned directly at the mRNA entrance channel. This is in agreement with previous studies investigating antisense-induced framesh.....
    Document: In this work, we report a strong correlation between the thermodynamic stability of the first 3-4 bp at the base of the stem-loop and frameshift efficiency in HIV-1. We therefore hypothesize that the frameshift mechanism involves a thermodynamic block to translocation, determined by the local stability of base pairs positioned directly at the mRNA entrance channel. This is in agreement with previous studies investigating antisense-induced frameshifting using either mixed locked nucleic acid/DNA (73) or morpholino/RNA (38) oligonucleotides. When these oligonucleotides were used to direct antisenseinduced frameshifting, the local stability of the duplex was also critical to frameshift stimulation (38, 73) .

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