Author: Wilton T. Snead; Wade F. Zeno; Grace Kago; Ryan W. Perkins; J Blair Richter; Chi Zhao; Eileen M. Lafer; Jeanne C. Stachowiak
Title: BAR scaffolds drive membrane fission by crowding disordered domains Document date: 2018_3_4
ID: drqseaaa_40
Snippet: Our work reveals a synergistic relationship between structured protein assemblies and disordered pressure generators, which can be harnessed to drive membrane fission. It is increasingly recognized that structural disorder is prevalent in membrane trafficking, and that disordered domains are often coupled to structured domains within the same protein molecules (Pietrosemoli et al., 2013) . While previous work has focused primarily on structure-fu.....
Document: Our work reveals a synergistic relationship between structured protein assemblies and disordered pressure generators, which can be harnessed to drive membrane fission. It is increasingly recognized that structural disorder is prevalent in membrane trafficking, and that disordered domains are often coupled to structured domains within the same protein molecules (Pietrosemoli et al., 2013) . While previous work has focused primarily on structure-function relationships revealed by studying individual protein domains, these findings highlight the importance of examining the collective contributions from both All rights reserved. No reuse allowed without permission.
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